What is breast cancer?
Breast cancer is a malignant tumor (a collection of cancer cells) arising from the cells of the breast. Although breast cancer predominantly occurs in women it can also affect men. This article deals with breast cancer in women.
Breast cancer facts
According to the American Cancer society:
What are breast cancer symptoms and signs?
The most common sign of breast cancer is a new lump or mass in the breast. In addition, the following are possible signs of breast cancer:
You should discuss these or any other findings that concern you with your health care professional.
How is breast cancer diagnosed?
Although breast cancer can be diagnosed by the above signs and symptoms, the use of screening mammography has made it possible to detect many of the cancers early before they cause any symptoms.
The American Cancer Society (ACS) has the following recommendations for breast cancer screenings:
Women age 40 and older should have a screening mammogram every year and should continue to do so as long as they are in good health.
Women should have a clinical breast exam (CBE) as part of regular health exams by a health care professional about every 3 years for women in their 20s and 30s and every year for women 40 years of age and over.
In contrast to the ACS recommendations, the U.S. Preventive Services Task Force recommends that routine mammography screening begin at age 50. Women aged 40 to 49 are encouraged to discuss their situation with their health care practitioner to decide on the appropriate time to begin screening mammography.
Breast self-exam (BSE) is an option for women starting in their 20s. Women should report any breast changes to their health care professional.
If a woman wishes to do BSE, the technique should be reviewed with her health care professional. The goal is to feel comfortable with the way the woman's breasts feel and look and, therefore, detect changes.
Women at high risk (greater than 20% lifetime risk) should get an MRI and a mammogram every year. Women at moderate risk (15% to 20%) should talk to their doctor about the benefits and limitations of adding MRI screening to their yearly mammogram.
Types of breast cancers
There are several types of breast cancer, but some of them are quite rare. In some cases a single breast tumor can be a combination of these types or be a mixture of invasive and in situ cancer.
Ductal carcinoma in situ
Ductal carcinoma in situ (DCIS; also known as intraductal carcinoma) is considered non-invasive or pre-invasive breast cancer. DCIS means that cells that lined the ducts have changed to look like cancer cells.
The difference between DCIS and invasive cancer is that the cells have not spread (invaded) through the walls of the ducts into the surrounding breast tissue. DCIS is considered a pre-cancer because some cases can go on to become invasive cancers. Right now, though, there is no good way to know for certain which cases will go on to become invasive cancers and which ones won’t.
About 1 in 5 new breast cancer cases will be DCIS. Nearly all women diagnosed at this early stage of breast cancer can be cured.
Lobular carcinoma in situ
In lobular carcinoma in situ (LCIS) cells that look like cancer cells grow in the lobules of the milk-producing glands of the breast, but they do not grow through the wall of the lobules. This is not a true cancer or pre-cancer, and is discussed in the section “What are the risk factors for breast cancer?”
Invasive (or infiltrating) ductal carcinoma
This is the most common type of breast cancer. Invasive (or infiltrating) ductal carcinoma (IDC) starts in a milk duct of the breast, breaks through the wall of the duct, and grows into the fatty tissue of the breast. At this point, it may be able to spread (metastasize) to other parts of the body through the lymphatic system and bloodstream. About 8 of 10 invasive breast cancers are infiltrating ductal carcinomas.
Invasive (or infiltrating) lobular carcinoma
Invasive lobular carcinoma (ILC) starts in the milk-producing glands (lobules). Like IDC, it can spread (metastasize) to other parts of the body. About 1 invasive breast cancer in 10 is an ILC. Invasive lobular carcinoma may be harder to detect by a mammogram than invasive ductal carcinoma.
Less common types of breast cancer
Inflammatory breast cancer:
This uncommon type of invasive breast cancer accounts for about 1% to 3% of all breast cancers. Usually there is no single lump or tumor. Instead, inflammatory breast cancer (IBC) makes the skin on the breast look red and feel warm. It also may give the breast skin a thick, pitted appearance that looks a lot like an orange peel. Doctors now know that these changes are not caused by inflammation or infection, but by cancer cells blocking lymph vessels in the skin. The affected breast may become larger or firmer, tender, or itchy.
In its early stages, inflammatory breast cancer is often mistaken for an infection in the breast (called mastitis) and treated as an infection with antibiotics. If the symptoms are caused by cancer, they will not improve, and a biopsy will find cancer cells. Because there is no actual lump, it might not show up on a mammogram, which can make it even harder to find it early. This type of breast cancer tends to have a higher chance of spreading and a worse outlook (prognosis) than typical invasive ductal or lobular cancer. For more details about this condition, see our document,Inflammatory Breast Cancer.
Triple-negative breast cancer: This term is used to describe breast cancers (usually invasive ductal carcinomas) whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. (See the section, "How is breast cancer diagnosed?" for more detail on these receptors.) Breast cancers with these characteristics tend to occur more often in younger women and in African-American women.
Triple-negative breast cancers tend to grow and spread more quickly than most other types of breast cancer. Because the tumor cells lack these certain receptors, neither hormone therapy nor drugs that target HER2 are effective treatments. Chemotherapy can still be useful, and is often recommended even for early-stage disease as it lowers the risk of the cancer coming back later.
Paget disease of the nipple: This type of breast cancer starts in the breast ducts and spreads to the skin of the nipple and then to the areola, the dark circle around the nipple. It is rare, accounting for only about 1% of all cases of breast cancer. The skin of the nipple and areola often appears crusted, scaly, and red, with areas of bleeding or oozing. The woman may notice burning or itching.
Paget disease is almost always associated with either ductal carcinoma in situ (DCIS) or infiltrating ductal carcinoma. Treatment often requires mastectomy. If no lump can be felt in the breast tissue, and the biopsy shows DCIS but no invasive cancer, the outlook (prognosis) is excellent. If invasive cancer is present, the prognosis is not as good, and the cancer will need to be staged and treated like any other invasive cancer.
Phyllodes tumor: This very rare breast tumor develops in the stroma (connective tissue) of the breast, in contrast to carcinomas, which develop in the ducts or lobules. Other names for these tumors include phylloides tumor andcystosarcoma phyllodes. These tumors are usually benign but on rare occasions may be malignant.
Benign phyllodes tumors are treated by removing the tumor along with a margin of normal breast tissue. A malignant phyllodes tumor is treated by removing it along with a wider margin of normal tissue, or by mastectomy. Surgery is often all that is needed, but these cancers might not respond as well to the other treatments used for more common breast cancers. When a malignant phyllodes tumor has spread, it can be treated with the chemotherapy given for soft-tissue sarcomas (this is discussed in detail in our document, Sarcoma - Adult Soft Tissue Cancer.
Angiosarcoma: This form of cancer starts in cells that line blood vessels or lymph vessels. It rarely occurs in the breasts. When it does, it usually develops as a complication of previous radiation treatments. This is an extremely rare complication of breast radiation therapy that can develop about 5 to 10 years after radiation. Angiosarcoma can also occur in the arms of women who develop lymphedema as a result of lymph node surgery or radiation therapy to treat breast cancer. (For information on lymphedema, see the section, "How is breast cancer treated?") These cancers tend to grow and spread quickly. Treatment is generally the same as for other sarcomas. See our document,Sarcoma - Adult Soft Tissue Cancer.
Special types of invasive breast carcinoma
There are some special types of breast cancer that are sub-types of invasive carcinoma. These are often named after features seen when they are viewed under the microscope, like the ways the cells are arranged.
Some of these may have a better prognosis than standard infiltrating ductal carcinoma. These include:
Some sub-types have the same or maybe worse prognosis than standard infiltrating ductal carcinoma. These include:
In general, all of these sub-types are still treated like standard infiltrating ductal carcinoma.
Breast cancer is a malignant tumor (a collection of cancer cells) arising from the cells of the breast. Although breast cancer predominantly occurs in women it can also affect men. This article deals with breast cancer in women.
Breast cancer facts
- Breast cancer is the most common cancer among American women.
- One in every eight women in the United States develops breast cancer.
- There are many types of breast cancer that differ in their capability of spreading (metastasizing) to other body tissues.
- The causes of breast cancer are not yet fully known although a number of risk factors have been ident
- Breast cancer is diagnosed with physician and self-examination of the breasts, mammography, ultrasound testing, and biopsy.
- Treatment of breast cancer depends on the type of cancer and its stage (the extent of spread in the body).
According to the American Cancer society:
- Over 230,000 new cases of invasive breast cancer are diagnosed each year.
- Nearly 40,000 women are expected to die of breast cancer in 2013.
- There are over 2.5 million breast cancer survivors in the United States.
- The recommendations regarding frequency and age when women should get screening mammography differ slightly between different organizations and task forces.
- Between 40 and 50 years of age, mammograms are recommended every 1 to 2 years (National Cancer Institute). After 50 years of age, yearly mammograms are recommended (American College of Obstetrics and Gynecology and U.S. Preventive Services Task Force).
- You should discuss with your health care professional the screening frequency that he or she recommends and what guidelines they follow.
- Patients with a family history or specific risk factors might have a different screening schedule including starting screening mammograms at an earlier age.
What are breast cancer symptoms and signs?
The most common sign of breast cancer is a new lump or mass in the breast. In addition, the following are possible signs of breast cancer:
- Nipple discharge or redness
- Breast or nipple pain
- Swelling of part of the breast or dimpling of the skin over the breast
You should discuss these or any other findings that concern you with your health care professional.
How is breast cancer diagnosed?
Although breast cancer can be diagnosed by the above signs and symptoms, the use of screening mammography has made it possible to detect many of the cancers early before they cause any symptoms.
The American Cancer Society (ACS) has the following recommendations for breast cancer screenings:
Women age 40 and older should have a screening mammogram every year and should continue to do so as long as they are in good health.
- Mammograms are a very good screening tool for breast cancer. As in any test, mammograms have limitations and will miss some cancers. The results of your mammogram, breast exam, and family history should be discussed with your health care professional.
Women should have a clinical breast exam (CBE) as part of regular health exams by a health care professional about every 3 years for women in their 20s and 30s and every year for women 40 years of age and over.
- CBE are an important tool to detect changes in your breasts and also trigger a discussion with your health care professional about early cancer detection and risk factors.
In contrast to the ACS recommendations, the U.S. Preventive Services Task Force recommends that routine mammography screening begin at age 50. Women aged 40 to 49 are encouraged to discuss their situation with their health care practitioner to decide on the appropriate time to begin screening mammography.
Breast self-exam (BSE) is an option for women starting in their 20s. Women should report any breast changes to their health care professional.
If a woman wishes to do BSE, the technique should be reviewed with her health care professional. The goal is to feel comfortable with the way the woman's breasts feel and look and, therefore, detect changes.
Women at high risk (greater than 20% lifetime risk) should get an MRI and a mammogram every year. Women at moderate risk (15% to 20%) should talk to their doctor about the benefits and limitations of adding MRI screening to their yearly mammogram.
Types of breast cancers
There are several types of breast cancer, but some of them are quite rare. In some cases a single breast tumor can be a combination of these types or be a mixture of invasive and in situ cancer.
Ductal carcinoma in situ
Ductal carcinoma in situ (DCIS; also known as intraductal carcinoma) is considered non-invasive or pre-invasive breast cancer. DCIS means that cells that lined the ducts have changed to look like cancer cells.
The difference between DCIS and invasive cancer is that the cells have not spread (invaded) through the walls of the ducts into the surrounding breast tissue. DCIS is considered a pre-cancer because some cases can go on to become invasive cancers. Right now, though, there is no good way to know for certain which cases will go on to become invasive cancers and which ones won’t.
About 1 in 5 new breast cancer cases will be DCIS. Nearly all women diagnosed at this early stage of breast cancer can be cured.
Lobular carcinoma in situ
In lobular carcinoma in situ (LCIS) cells that look like cancer cells grow in the lobules of the milk-producing glands of the breast, but they do not grow through the wall of the lobules. This is not a true cancer or pre-cancer, and is discussed in the section “What are the risk factors for breast cancer?”
Invasive (or infiltrating) ductal carcinoma
This is the most common type of breast cancer. Invasive (or infiltrating) ductal carcinoma (IDC) starts in a milk duct of the breast, breaks through the wall of the duct, and grows into the fatty tissue of the breast. At this point, it may be able to spread (metastasize) to other parts of the body through the lymphatic system and bloodstream. About 8 of 10 invasive breast cancers are infiltrating ductal carcinomas.
Invasive (or infiltrating) lobular carcinoma
Invasive lobular carcinoma (ILC) starts in the milk-producing glands (lobules). Like IDC, it can spread (metastasize) to other parts of the body. About 1 invasive breast cancer in 10 is an ILC. Invasive lobular carcinoma may be harder to detect by a mammogram than invasive ductal carcinoma.
Less common types of breast cancer
Inflammatory breast cancer:
This uncommon type of invasive breast cancer accounts for about 1% to 3% of all breast cancers. Usually there is no single lump or tumor. Instead, inflammatory breast cancer (IBC) makes the skin on the breast look red and feel warm. It also may give the breast skin a thick, pitted appearance that looks a lot like an orange peel. Doctors now know that these changes are not caused by inflammation or infection, but by cancer cells blocking lymph vessels in the skin. The affected breast may become larger or firmer, tender, or itchy.
In its early stages, inflammatory breast cancer is often mistaken for an infection in the breast (called mastitis) and treated as an infection with antibiotics. If the symptoms are caused by cancer, they will not improve, and a biopsy will find cancer cells. Because there is no actual lump, it might not show up on a mammogram, which can make it even harder to find it early. This type of breast cancer tends to have a higher chance of spreading and a worse outlook (prognosis) than typical invasive ductal or lobular cancer. For more details about this condition, see our document,Inflammatory Breast Cancer.
Triple-negative breast cancer: This term is used to describe breast cancers (usually invasive ductal carcinomas) whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. (See the section, "How is breast cancer diagnosed?" for more detail on these receptors.) Breast cancers with these characteristics tend to occur more often in younger women and in African-American women.
Triple-negative breast cancers tend to grow and spread more quickly than most other types of breast cancer. Because the tumor cells lack these certain receptors, neither hormone therapy nor drugs that target HER2 are effective treatments. Chemotherapy can still be useful, and is often recommended even for early-stage disease as it lowers the risk of the cancer coming back later.
Paget disease of the nipple: This type of breast cancer starts in the breast ducts and spreads to the skin of the nipple and then to the areola, the dark circle around the nipple. It is rare, accounting for only about 1% of all cases of breast cancer. The skin of the nipple and areola often appears crusted, scaly, and red, with areas of bleeding or oozing. The woman may notice burning or itching.
Paget disease is almost always associated with either ductal carcinoma in situ (DCIS) or infiltrating ductal carcinoma. Treatment often requires mastectomy. If no lump can be felt in the breast tissue, and the biopsy shows DCIS but no invasive cancer, the outlook (prognosis) is excellent. If invasive cancer is present, the prognosis is not as good, and the cancer will need to be staged and treated like any other invasive cancer.
Phyllodes tumor: This very rare breast tumor develops in the stroma (connective tissue) of the breast, in contrast to carcinomas, which develop in the ducts or lobules. Other names for these tumors include phylloides tumor andcystosarcoma phyllodes. These tumors are usually benign but on rare occasions may be malignant.
Benign phyllodes tumors are treated by removing the tumor along with a margin of normal breast tissue. A malignant phyllodes tumor is treated by removing it along with a wider margin of normal tissue, or by mastectomy. Surgery is often all that is needed, but these cancers might not respond as well to the other treatments used for more common breast cancers. When a malignant phyllodes tumor has spread, it can be treated with the chemotherapy given for soft-tissue sarcomas (this is discussed in detail in our document, Sarcoma - Adult Soft Tissue Cancer.
Angiosarcoma: This form of cancer starts in cells that line blood vessels or lymph vessels. It rarely occurs in the breasts. When it does, it usually develops as a complication of previous radiation treatments. This is an extremely rare complication of breast radiation therapy that can develop about 5 to 10 years after radiation. Angiosarcoma can also occur in the arms of women who develop lymphedema as a result of lymph node surgery or radiation therapy to treat breast cancer. (For information on lymphedema, see the section, "How is breast cancer treated?") These cancers tend to grow and spread quickly. Treatment is generally the same as for other sarcomas. See our document,Sarcoma - Adult Soft Tissue Cancer.
Special types of invasive breast carcinoma
There are some special types of breast cancer that are sub-types of invasive carcinoma. These are often named after features seen when they are viewed under the microscope, like the ways the cells are arranged.
Some of these may have a better prognosis than standard infiltrating ductal carcinoma. These include:
- Adenoid cystic (or adenocystic) carcinoma
- Low-grade adenosquamous carcinoma (this is a type of metaplastic carcinoma)
- Medullary carcinoma
- Mucinous (or colloid) carcinoma
- Papillary carcinoma
- Tubular carcinoma
Some sub-types have the same or maybe worse prognosis than standard infiltrating ductal carcinoma. These include:
- Metaplastic carcinoma (most types, including spindle cell and squamous)
- Micropapillary carcinoma
- Mixed carcinoma (has features of both invasive ductal and lobular)
In general, all of these sub-types are still treated like standard infiltrating ductal carcinoma.